Genomic mosaicism in two strains of dengue virus type 3
Autor(es): Villabona-Arenas, Christian Julian; de Brito, Anderson Fernandes; de Andrade Zanotto, Paolo Marinho
Resumo: Recombination is a significant factor driving genomic Evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses. (C) 2013 Elsevier B.V. All rights reserved.
Palavras-Chave: Dengue Virus Type 3; Phylogeny; Recombination; Split Decomposition
Imprenta: Infection Genetics And Evolution, v. 18, p. 202-212, 2013
Identificador do objeto digital: 10.1016/j.meegid.2013.05.012
Descritores: Aedes aegypti - Genome ; Aedes aegypti - RNA ; Aedes aegypti - Dengue
Data de publicação: 2013
