Autor(es): Sim, Shuzhen; Hibberd, Martin L.

Resumo: The incidence and geographic range of dengue have increased dramatically in recent decades. Climate change, rapid urbanization and increased global travel have facilitated the spread of both efficient mosquito vectors and the four dengue virus serotypes between population centers. At the same time, significant advances in Genomics approaches have provided insights into host-pathogen interactions, Immunogenetics, and viral Evolution in both humans and mosquitoes. Here, we review these advances and the innovative treatment and control strategies that they are inspiring.

Palavras-Chave: Mosquito Aedes-Aegypti; Quantitative Trait Loci; Blood Mononuclear-Cells; Naturally Infected Mosquitos; Gene Transcript Abundance; Life-Shortening Wolbachia; Engineered Male Mosquitos; Placebo-Controlled Trial; West-Nile-Virus; Hemorrhagic-Fever

Imprenta: Genome Biology, v. 17, n. 38, 2016

Identificador do objeto digital: 10.1186/s13059-016-0907-2

Descritores: Aedes aegypti - Vaccine ; Aedes aegypti - Public health

Data de publicação: 2016