Autor(es): Vontas, J; Siden-Kiamos, I; Papagiannakis, G; Karras, M; Waters, AP; Louis, C

Resumo: Using an in vitro development system for Plasmodium berghei sporogonic stages and microarray technology we examined parasite gene expression during ookinete invasion of Aedes cells and the ensuing oocyst development. A number of genes were found to be differentially expressed. The most prominent class of up-regulated elements corresponded to products involved in protein synthesis and metabolism. Furthermore, several previously studied genes with a known in vivo developmental profile matched published data. A large number of genes with a hitherto unknown function during the life cycle stages studied also show a differential pattern of expression, indicating the involvement of their products in control and execution of active developmental processes. (c) 2005 Elsevier B.V. All rights reserved.

Palavras-Chave: Anopheles-Stephensi; Genome Sequence; Parasite; Protein; Infection; Antigens; Invasion; Surface

Imprenta: Molecular and Biochemical Parasitology, v. 140, n. 2, p. 251-+, 2005

Identificador do objeto digital: 10.1016/j.molbiopara.2005.01.008

Descritores: Aedes aegypti - Protein synthesis

Data de publicação: 2005