Autor(es): Munoz, M. D.; Cisneros, A.; Cruz, J.; Das, P.; Tovar, R.; Ortega, A.

Resumo: Dengue viruses are arthropod-borne, single-stranded RNA viruses. Aedes aegypti and Aedes albopictus are the principal vectors. In order to understand the molecular basis of dengue virus infections ne explored the biochemical identity of dengue-2 (DEN-2) virus receptors in the Aedes albopictus-derived cell line C6/36. We show here that DEN-2 interacts with two major polypeptides of 80 and 67 kDa. Polyclonal anti-C6/36 membrane antibodies block DEN-2 binding to intact C6/36 monolayers as well as to membrane extracts. Our results strongly suggest thar the identified polypeptides are part of the DEN-2 receptors. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

Palavras-Chave: Dengue virus; Receptor; C6/36 cell

Imprenta: Fems Microbiology Letters, v. 168, n. 2, p. 251-258, 1998

Identificador do objeto digital: 10.1111/j.1574-6968.1998.tb13281.x

Descritores: Aedes aegypti - Cell ; Aedes aegypti - RNA

Data de publicação: 1998

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