Autor(es): Guzman, Maria G.; Harris, Eva

Resumo: Dengue viruses have spread rapidly within countries and across regions in the past few decades, resulting in an increased frequency of epidemics and severe dengue disease, hyperendemicity of multiple dengue virus serotypes in many tropical countries, and autochthonous transmission in Europe and the USA. Today, dengue is regarded as the most prevalent and rapidly spreading mosquito-borne viral disease of human beings. Importantly, the past decade has also seen an upsurge in research on dengue virology, pathogenesis, and immunology and in development of antivirals, vaccines, and new vector-control strategies that can positively impact dengue control and prevention.

Palavras-Chave: Antibody - Dependent enhancement; Randomized controlled - Trial; Placebo - Controlled trial; Original antigenic sin; Cd8(+) T-Cells; Hemorrhagic - Fever; Virus - Infection; Aedes aegypti; Vascular leakage; Protective efficacy

Imprenta: The Lancet, v. 385, n. 9966, p. 453-465, 2015

Identificador do objeto digital: 10.1016/S0140-6736(14)60572-9

Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Immunology

Data de publicação: 2015