Coumarin derivatives from Esenbeckia grandiflora and its larvicidal activity against Aedes aegypti
Autor(es): de Oliveira, PES; Conserva, LM; Brito, AC; Lemos, RPL
Resumo: From a hexane fraction prepared from the roots of Esenbeckia grandiflora Mart., effective against fourth instar larvae of Aedes aegypti L. (LC50 108.23 ppm), eight coumarin derivatives [daphnetin 7-methyl-8-(3,3-dimethylallyl) ether, a mixture containing pimpinellin eight one of its photodimerization product, 5-senecloylxanthotoxin, 3-(1',1')-dimethylallylcolumbianetin, swietenocoumarin B, isopimpinellin, xanthotoxin, and 5-(1'-hydroxyisopentenyl)bergapten] were isolated in addition to sitosterol and sitostenone. The mixture containing pimpinellin and its photodimerization product was effective against fourth instar larvae (LC50 at 45.77 ppm), and a mixture of pimpinellin and swietenocoumarin B showed a LC50 value of 62.23 ppm. All isolated compounds were identified on the basis of the spectral data including 2D experiments. Furthermore, previously unreported spectral data for some compounds are given.
Palavras-Chave: Aedes aegypti; Coumarin derivatives; Esenbeckia grandiflora; Larvicidal activity
Imprenta: Pharmaceutical Biology, v. 43, n. 1, p. 53-57, 2005
Identificador do objeto digital: 10.1080/13880200590903363
Descritores: Aedes aegypti - Larvicide
Data de publicação: 2005
