Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts
Autor(es): Cruz, Sully M.; Caceres, Armando; Alvarez, Luis; Morales, Julio; Apel, Miriam A.; Henriques, Amelia T.; Salamanca, Efrain; Gimenez, Alberto; Vasquez, Yelkaira; Gupta, Mahabir P.
Resumo: The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 mu g/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 mu g/mL), and epimastigotes of Trypanosoma cruzi (51.9 mu g/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 mu g/mL), and the dichloromethane extract against Leishmania (55.8-76.3 mu g/mL) and T. cruzi (45.8 mu g/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.
Palavras-Chave: Antimicrobial activity; Cytotoxic activity; Essential oil; Extracts; Guatemala; Piper
Imprenta: Revista Brasileira de Farmacognosia, v. 21, n. 4, p. 587-593, 2011
Identificador do objeto digital: 10.1590/S0102-695X2011005000110
Descritores: Aedes aegypti - Biochemistry
Data de publicação: 2011
