Characterization of Aedes albopictus akirin for the control of mosquito and sand fly infestations
Autor(es): Moreno-Cid, Juan A.; Jimenez, Maribel; Cornelie, Sylvie; Molina, Ricardo; Alarcon, Pedro; Lacroix, Marie-Noelle; Pinal, Rocio; Delacour, Sarah; Lucientes, Javier; Canales, Mario; Perez de la Lastra, Jose M.; Villar, Margarita; de la Fuente, Jose
Resumo: The control of arthropod vectors of pathogens that affect human and animal health is important for the eradication of vector-borne diseases. Recent evidences showed a reduction in the survival and/or fertility of mosquitoes, sand flies and poultry red mites fed in vitro with antibodies against the recombinant Aedes albopictus akirin. These experiments were the first step toward the development of a multi-target arthropod vaccine. In this study, we showed that the oviposition of A. albopictus and Phlebotomus perniciosus fed on mice vaccinated with recombinant A. albopictus akirin was reduced by 17% and 31%, respectively when compared to controls. However, Aedes aegypti mosquitoes were not affected after feeding on vaccinated mice. These results showed that recombinant A. albopictus akirin could be used to vaccinate hosts for the control of mosquito and sand fly infestations and suggested new experiments to develop improved vaccine formulations. (C) 2010 Elsevier Ltd. All rights reserved.
Palavras-Chave: Akirin; Arthropod; Mosquito; Sand fly; Subolesin; Tick; Vaccine
Imprenta: Vaccine, v. 29, n. 1, p. 77-82, 2010
Identificador do objeto digital: 10.1016/j.vaccine.2010.10.011
Descritores: Aedes aegypti - Immune response ; Aedes aegypti - Molecular structure ; Aedes aegypti - Immunology ; Aedes aegypti - Public health
Data de publicação: 2010
