Autor(es): Merkling, Sarah H.; van Rij, Ronald P.

Resumo: Virus transmission and spread by arthropods is a major economic and public health concern. The ongoing dissemination of arthropod-borne viruses by blood-feeding insects is an important incentive to study antiviral immunity in these animals. RNA interference is a major mechanism for antiviral defense in insects, including the fruit fly Drosophila melanogaster and several vector mosquitoes. However, recent data suggest that the evolutionary conserved Toll, Imd and Jak-Stat signaling pathways also contribute to antiviral immunity. Moreover, symbionts, such as the intracellular bacterium Wolbachia and the gut microflora, influence the course of virus infection in insects. These results add an additional level of complexity to antiviral immunity, but also provide novel opportunities to control the spread of arboviruses. In this review, we provide an overview of the current knowledge and recent developments in antiviral immunity in Dipteran insects, with a focus on non-RNAi mediated inducible responses. (C) 2012 Published by Elsevier Ltd.

Palavras-Chave: Virus; Arbovirus; Innate immunity; Insect; Toll pathway; Imd pathway

Imprenta: Journal of Insect Physiology, v. 59, n. 2, p. 159-170, 2013

Identificador do Objeto Digital: 10.1016/j.jinsphys.2012.07.004

Descritores: Aedes aegypti - Arbovirus ; Aedes aegypti - Genome ; Aedes aegypti - Immune response ; Aedes aegypti - Molecular structure ; Aedes aegypti - RNA ; Aedes aegypti - Immunology ; Aedes aegypti - Viral infections ; Aedes aegypti - Public health

Data de Publicação: 2013