Autor(es): Polizel, JR; Bueno, D; Visentainer, JEL; Sell, AM; Borelli, SD; Tsuneto, LT; Dalalio, MMO; Coimbra, MTM; Moliterno, RA

Resumo: Dengue is an infectious disease of viral etiology transmitted by the mosquitoes Aedes aegypti, A. albopictus, and A. scutellaris. It can develop either as a benign form or as a severe hemorrhagic form. Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA), suggesting a role of genetic factors in disease susceptibility. Nevertheless, data on HLA association with the classical form of the disease is scarce in literature. Sixty-four patients and 667 normal individuals, living in the state of Paranca, Southern Brazil, were used as test and control group, respectively. The patients developed the disease during a virus 1 dengue outbreak either in Maringa city in 1995 (47) or in Paranavai city in 1999 (17). The diagnostic was confirmed through serology and/or viral culture. HLA class I and II typing was performed by the classical microlynfocitotoxicity test using monoclonal antisera and fluorobeads. Qui-square statistical analysis confirmed a positive association with HLA-DQI (76.6% vs 57.7%; p = 0.005243; pc = 0.026215). HLA-DR1 also presented an increased frequency in the test group, not statistically significant after p correction though (32.8% vs 15.9%; p = 0.005729; pc = 0.080206). In conclusion, genetic factors may play a role on the susceptibility to the classical dengue, virus 1, in the Brazilian population. Further independent studies should be performed in the Brazilian population to confirm these preliminary data.

Palavras-Chave: Human leukocyte antigens; Dengue fever; Brazil

Imprenta: Memorias do Instituto Oswaldo Cruz, v. 99, n. 6, p. 559-562, 2004

Identificador do objeto digital: 10.1590/S0074-02762004000600003

Descritores: Aedes aegypti - T lymphocytes ; Aedes aegypti - Serology ; Aedes aegypti - Epidemiology ; Aedes aegypti - Public health

Data de publicação: 2004

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