Antioxidant, larvicidal and antiacetylcholinesterase activities of cashew nut shell liquid constituents
Autor(es): Costa Oliveira, Micheline Soares; de Morais, Selene Maia; Magalhaes, Davi Varela; Batista, Williams Pereira; Pinto Vieira, Icaro Gusmao; Craveiro, Afranio Aragao; Silva Alencar de Manezes, Jane Eire; Urano Carvalho, Ana Fontenelle; Gomes de Lima, Glauber Pacelli
Resumo: Anacardic acid, cardanol and cardol. the main constituents of natural cashew nut shell liquid (CNSL), were obtained by solvent extraction and assayed for antioxidant, larvicidal and antiacetylcholinesterase activity. Their relative percent composition was obtained by HPLC analysis. Antioxidant activity was assessed using the DPPH and ABTS(center dot+) tests, which showed cardanol as the most active, followed by cardol and anacardic acid. The three CNSL components demonstrated good larvicidal activity against Aedes aegypti (LC(50) = 12.40 for anacardic acid, 10.22 for cardol and 14.45 for cardanol) and exhibited inhibition zones for acetylcholinesterase enzymes in the TLC test similar to carbachol, which was used as standard. Based on the results, these multipotent compounds represent promising agents in the control of Ae. aegypti, the main dengue vector in Brazil. (C) 2011 Published by Elsevier B.V.
Palavras-Chave: CNSL; Antiradical; Larvicide; Acetylcholinesterase inhibition
Imprenta: Acta Tropica, v. 117, n. 3, p. 165-170, 2011
Identificador do objeto digital: 10.1016/j.actatropica.2010.08.003
Descritores: Aedes aegypti - Larvicide
Data de publicação: 2011
