Emergence and clinical insights into the pathology of Chikungunya virus infection
Autor(es): Jaffar-Bandjee, Marie Christine; Ramful, Duksha; Gauzere, Bernard Alex; Hoarau, Jean Jacques; Krejbich-Trotot, Pascale; Robin, Stephanie; Ribera, Anne; Selambarom, Jimmy; Gasque, Philippe
Resumo: Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the alphavirus Chikungunya, and is transmitted by Aedes mosquitoes. The infection is highly symptomatic, with fever, skin rash and incapacitating arthralgia, which can evolve to chronic arthritis and rheumatism in elderly patients. Mother-to-child transmission, encephalitis, Guillain-Barre syndrome and deaths have been noted. In this article, we will highlight the epidemiological, clinical, virological and immunological aspects of the disease and mention the therapies that have been used during recent epidemics. Novel prevention measures to control the mosquito and a new vaccine are highly warranted.
Palavras-Chave: Symptoms; Epidemics; Pathology; Therapy; Pest control; Vaccines; Aquatic insects; Disease transmission; Public health; Skin; Encephalitis; Immunological aspects; Fever; Exanthema; Guillain-Barre syndrome; Rheumatism; Arthritis; Chronic infection; Geriatrics; Arthralgia; Aedes; Chikungunya virus; Alphavirus
Imprenta: Expert Review of Anti-infective Therapy, v. 8, n. 9, p. 987-996, 2010
Descritores: Guillain-Barre Syndrome and Immunology ; Guillain-Barre Syndrome and virus ; Guillain-Barre Syndrome and Transmission ; Guillain-Barre Syndrome and Vaccine ; Guillain-Barre Syndrome and Chikungunya Fever ; Guillain-Barre Syndrome and Epidemic ; Guillain-Barre Syndrome and Public health
Data de publicação: 2010
