Vector competence in west african Aedes aegypti is flavivirus species and genotype dependent
Autor(es): Dickson, Laura B.; Sanchez-Vargas, Irma; Sylla, Massamba; Fleming, Karen; Black, William C.
Resumo: Vector competence is defined as the intrinsic permissiveness of an arthropod vector for infection, dissemination, and transmission of a pathogen. The mosquito Aedes aegypti is the main vector for dengue and yellow fever viruses worldwide and is divided into two subspecies: Ae. aegypti aegypti and Ae. aegypti formosus. Aedes aegypti aegypti is found globally in tropical and subtropical regions, while Ae. aegypti formosus is mainly restricted to sub-Saharan Africa. Aedes aegypti formosus is considered to be a poor vector for both yellow fever and dengue, but some of these original studies with yellow fever were performed with highly passaged viral isolates collected at different locations than the mosquitoes. Viral genetics is an important determinant of vector competence and virus/mosquito genetic specificity exists in Ae. aegypti aegypti. We compared the vector competence of multiple collections of Ae. aegypti from throughout Senegal for both yellow fever and dengue viruses to demonstrate that vector competence in Ae. aegypti formosus is dependent on viral genotype. In contrast to earlier claims, populations of Ae. aegypti in West Africa can be competent vectors of flaviviruses.
Palavras-Chave: Human diseases; Viral diseases; Viruses; Pathogens; Genotypes; Hosts; Aquatic insects; Public health; Disease transmission; Dengue; Yellow fever; Vectors; Infection; Aedes aegypti; Arthropoda; Flavivirus
Imprenta: Plos Neglected Tropical Diseases, v. 8, n. 10, 2014.
Descritores: Aedes aegypti - Viral infections ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Public health ; Aedes aegypti - Immunology
Data de publicação: 2014
