Autor(es): Faulde, Michael K; Nehring, Oliver

Resumo: New and improved strategies for malaria control and prevention are urgently needed. As a contribution to an optimized personal protection strategy, a novel long-lasting insecticide and repellent-treated net (LLIRN) has been designed by binding combinations of permethrin plus N,N-diethyl-m-toluamide (DEET), or insect repellent 3535 (IR3535), and etofenprox plus DEET, onto fibres of bed net fabric employing a new multi-layer polymer-coating technique. Protective repellent efficacy, toxicological effectiveness and residual activity of 12 LLIRN types have been evaluated by laboratory testing against adult Aedes aegypti. The novel multi-layer LLIRN design allowed simultaneous embedding at concentrations up to 5,930 mg/m2 for DEET, 3,408 mg/m2 for IR3535, 2,296 mg/m2 for permethrin and 2,349 mg/m2 for etofenprox, respectively. IR3535 layers prevented co-binding of additional pyrethroid-containing polymer layers, thus making pyrethroids plus DEET LLIRNs an ideal combination. All LLIRNs revealed synergistic insecticidal effects which, when measured against concentration controls of the isolated compounds, were significant in all LLIRN types designed. DEET in DEET plus permethrin LLIRNs significantly (p?

Palavras-Chave: Landing statistics; Human diseases; Insecticides; Repellents; Disease control; Malaria; Toxicity; Aquatic insects; Repellency; Bites; Permethrin; Embedding; Nets; Fabrics; DEET; Biting; Pyrethroids; Aedes aegypti

Imprenta: Parasitology Research, v. 111, n. 2, p. 755-765, 2012.

Descritores: Aedes aegypti - Repellent

Data de Publicação: 2012