Autor(es): Mori, A.; Chadee, D. D.; Graham, D. H.; Severson, D. W.

Resumo: We have initiated efforts to determine the molecular basis for the MD meiotic drive system in the mosquito, Aedes aegypti. The effect of the MD gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder ms allele. The MD system has potential as a mechanism for driving trangenes for pathogen resistance into natural Ae. aegypti populations. Because all previously existing laboratory strains carrying the MD gene have been lost, we have selected for a new strain, T37, that carries a strong driver. Matings between T37 males and drive-susceptible ms females result in progeny with highly biased sex ratios, wherein only approximately 14.7% females are produced. We discuss the potential for identifying MD candidate genes based on comparisons with the well-described Drosophila melanogaster segregation distorter (SD) meiotic drive system and considerations for release of transgenic Ae. aegypti into natural populations where MD and insensitive mi alleles are likely segregating.

Palavras-Chave: Sex ratio; Population replacement; Transgenic insects; Genetic control; Selection

Imprenta: Journal of Medical Entomology, v. 41, n. 6, p. 1027-1033, 2004.

Descritores: Aedes aegypti - Cell

Data de publicação: 2004

INDICADORES

ACESSO