Regulation of the ferritin heavy-chain homologue gene in the yellow fever mosquito, Aedes aegypti
Autor(es): Pham, D. Q. D.; Douglass, P. L.; Chavez, C. A.; Shaffer, J. J.
Resumo: In the yellow fever mosquito Aedes aegypti, the ferritin heavy-chain homologue (HCH) gene is induced by blood feeding. This suggests that ferritin may serve as a cytotoxic protector against the oxidative challenge of the blood meal and may be essential for the survival of the insect. In this study, various cis-acting elements for the gene were identified and mapped. Transfection assays showed that the strength and activity of a subset of these elements are orientation-dependent. The shift observed for the ferritin HCH cis-acting elements is unique among known ferritin genes. DNase I footprinting data together with Transfac analyses identified a number of putative sites known for their involvement in developmental and cell proliferation processes.
Palavras-Chave: Yellow fever mosquito
Imprenta: Insect Molecular Biology, v. 14, n. 3, p. 223-236, 2005.
Descritores: Aedes aegypti - Cell
Data de publicação: 2005
