Genetic control of enzyme structure in hyperuricemia.
Autor(es): Inwang, E. E.
Resumo: (1) A correlation has been made between the hyperuricemic condition in one of the polymorphic forms of Aedes aegypti larvae (yellow) and a structural modification in the molecular organization of the enzyme xanthine dehydrogenase. (2) There is differential accumulation of xanthine and hypoxanthine in the wild type and uric acid in the mutant yellow; these purines were partial inhibitors of XDH. (3) The nutritional conditions of rearing determined the degree of hyperuricemia: the hybrid produced more uric acid than either homozygotes when reared with high concentrations of food suggesting polygenic regulation. (4) Application of these results to the explanation of human hyperuricemia is discussed.
Imprenta: Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, v. 39, n. 3, p. 569-577, 1971.
Descritores: Aedes aegypti - Molecular Structure
Data de publicação: 1971
