Autor(es): Blitzer, E. J.; Vyazunova, I.; Lan, Q.

Resumo: The effect of gene expression knockdown was used to study the function of the sterol carrier protein-2 (AeSCP-2) in the yellow fever mosquito, Aedes aegypti. Injection of small double stranded AeSCP-2 RNAs into mosquito larvae resulted in the knockdown of gene products. The lack of AeSCP-2 in larvae coincided with a reduction in accumulated cholesterol in pupae, supporting the hypothesis that AeSCP-2 may be involved in cholesterol uptake in mosquito larvae. Knockdown of AeSCP-2 caused a high mortality rate in developing adult and reduced egg viability. Results from this study indicate that AeSCP-2 is important for adult development and for the viability of the eggs.

Palavras-Chave: Sterol carrier protein-2; RNAi; Fertility; Adultdevelopment; Cholesterol

Imprenta: Insect Molecular Biology, v. 14, n. 3, p. 301-307, 2005.

Descritores: Aedes aegypti - Proteins ; Aedes aegypti - RNA

Data de publicação: 2005

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