Enhancement of Cry19Aa mosquitocidal activity against Aedes aegypti by mutations in the putative loop regions of domain II

Autor(es): Abdullah, M. A. F.; Dean, D. H.


Resumo: Improvements in the mosquitocidal activity of Bacillus thuringiensis Cry19Aa were achieved by protein engineering of putative surface loop residues in domain II through rational design. The improvement of Aedes toxicity in Cry19Aa was 42,000-fold and did not affect its toxicity against Anopheles or Culex.


Palavras-Chave: Biological control; Mutations; Microbiology; Pest control; Toxicity; Aquatic insects; Protein engineering; Mutation


Imprenta: Applied and Environmental Microbiology, v. 70, n. 6, p. 3769-3771, 2004.


Descritores: Aedes aegypti - Proteins


Data de publicação: 2004