New constituents from the dried fruit of Piper nigrum Linn., and their larvicidal potential against the Dengue vector mosquito Aedes aegypti
Autor(es)Gulzar, Tahsin; Uddin, Nizam; Siddiqui, Bina Shaheen; Naqvi, Syed N. H.; Begum, Sabira; Tariq, Rajput Muhammed
ResumoSix bioactive compounds were isolated from the seeds extract of Piper nigrum Linn. following a larvicidal activity guided isolation against 4th instar larvae of Aedes aegypti L., a Dengue vector mosquito and a carrier of yellow fever. Their structures were elucidated using spectroscopic methods including HR-EIMS, FAB-MS, H-1 and C-13 NMR (Broad Bond Decoupled, & DEPT), and 2D-NMR techniques (H-1-H-1 COSY, NOESY, HMQC, HMBC, & 2D-J-resolved). These include three new constituents namely pipilyasine (1), pipzubedine (2) and pipyaqubine (3), and three known constituents pellitorine (4), pipericine (5) and piperine (6). The larvicidal activity was determined by WHO method. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
Palavras-ChavePiper nigrum Linn; Larvicidal activity; Aedes aegypti L.; Pipilyasine; Pipzubedine; Pipyaqubine
ImprentaPhytochemistry Letters, v. 6, n. 2, p. 219-223, 2013
Identificador do Objeto Digital10.1016/j.phytol.2013.01.006
DescritoresAedes aegypti - Larvicide ; Aedes aegypti - Public health
Data de Publicação:2013
