Mtx toxins from Lysinibacillus sphaericus enhance mosquitocidal cry-toxin activity and suppress cry-resistance in Culex quinquefasciatus
Autor(es): Wirth, Margaret C.; Berry, Colin; Walton, William E.; Federici, Brian A.
Resumo: The interaction of Mtx toxins from Lysinibacillus sphaericus (formerly Bacillus sphaericus) with Bacillus thuringiensis subsp. israelensis Cry toxins and the influence of such interactions on Cry-resistance were evaluated in susceptible and Cry-resistant Culex quinquefasciatus larvae. Mtx-1 and Mtx-2 were observed to be active against both susceptible and resistant mosquitoes; however varying levels of cross-resistance toward Mtx toxins were observed in the resistant mosquitoes. A 1:1 mixture of either Mtx-1 or Mtx-2 with different Cry toxins generally showed moderate synergism, but some combinations were highly toxic to resistant larvae and suppressed resistance. Toxin synergy has been demonstrated to be a powerful tool for enhancing activity and managing Cry-resistance in mosquitoes, thus Mtx toxins may be useful as components of engineered bacterial larvicides. (C) 2013 Elsevier Inc. All rights reserved.
Palavras-Chave: Mtx toxins; Cry toxins; Synergy; Resistance; Resistance Management
Imprenta: Journal of Invertebrate Pathology, v. 115, n. , p. 62-67, 2014
Identificador do objeto digital: 10.1016/j.jip.2013.10.003
Descritores: Aedes aegypti - Larvicide
Data de publicação: 2014
