EXTRACTS OF MOSQUITO SALIVARY-GLAND INHIBIT TUMOR-NECROSIS-FACTOR-ALPHA RELEASE FROM MAST-CELLS
Autor(es): BISSONNETTE, EY; ROSSIGNOL, PA; BEFUS, AD
Resumo: Extracts of salivary glands of the yellow fever mosquito Aedes aegypti inhibit tumour cell-stimulated release of tumour necrosis factor alpha (TNFalpha) from rat mast cells, but do not inhibit antigen-induced histamine secretion. This inhibitory activity for TNFalpha is found in salivary glands of female but not in male mosquitoes. This inhibition is not mediated by bacterial contamination (LPS), by calcitonin gene related peptide (CGRP), nerve growth factor (NGF), epidermal growth factor (EGF) or transforming growth factor beta (TGFbeta). The factor(s) has a molecular weight > 10 kDa and is neutralized by boiling for 10 min or heating at 56-degrees-C for 30 min. The modulation of this proinflammatory mediator, TNFalpha, produced by mast cells in sites of blood feeding may facilitate completion of the blood meal, and as reported for certain vector-transmitted parasites, may enhance infectivity.
Palavras-Chave: Aedes-Aegypti; Mosquito-Salivary Gland; Tnf-Alpha; Mast Cells
Imprenta: Parasite Immunology, v. 15, n. 1, p. 27-33, 1993
Identificador do objeto digital: 10.1111/j.1365-3024.1993.tb00569.x
Descritores: Aedes aegypti - Cell
Data de publicação: 1993
