Experimental Transmission of Mayaro Virus by Aedes aegypti
Autor(es): Long, Kanya C.; Ziegler, Sarah A.; Thangamani, Saravanan; Hausser, Nicole L.; Kochel, Tadeusz J.; Higgs, Stephen; Tesh, Robert B.
Resumo: Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae. aegypti ranged from 0% (0/31) to 84% (31/37), with blood meal virus titers between 3.4 log(10) and 7.3 log(10) plaque-forming units (PFU)/mL. Transmission of MAYV by 70% (21/30) of infected mosquitoes was shown by saliva collection and exposure to suckling mice. Amount of viral RNA in febrile humans, determined by real-time polymerase chain reaction, ranged from 2.7 to 5.3 log(10) PFU equivalents/mL. Oral susceptibility of Ae. aegypti to MAYV at titers encountered in viremic humans may limit opportunities to initiate an urban cycle; however, transmission of MAYV by Ae. aegypti shows the vector competence of this species and suggests potential for urban transmission.
Palavras-Chave: Venezuelan-Equine-Encephalitis; Valley Fever Virus; West-Nile-Virus; St-Louis Encephalitis; Yellow-Fever;Oral Infection; Encephalomyelitis Virus; Nonvascular Delivery; Geographic Strains; Chikungunya Virus
Imprenta: American Journal of Tropical Medicine and Hygiene, v. 85, n. 4, p. 750-757, 2011
Identificador do objeto digital: 10.4269/ajtmh.2011.11-0359
Descritores: Aedes aegypti - Chikungunya Fever ; Aedes aegypti - Public health
Data de publicação: 2011
