Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions
Autor(es): Santos, Clisiane C. S.; Araujo, Silvan S.; Santos, Andre L. L. M.; Almeida, Elis C. V.; Dias, Antonio S.; Damascena, Nicole P.; Santos, Deisylaine M.; Santos, Matheus I. S.; Junior, Karlos A. L. R.; Pereira, Carla K. B.; Lima, Amanda C. B.; Shan, Andrea Y. K. V.; Sant'ana, Antonio E. G.; Estevam, Charles S.; Araujo, Brancilene S.
Resumo: Dengue fever and schistosomiasis are major public health issues for which vector control using larvicide and molluscicide substances present in plants provides a promising strategy. This study evaluated the potential toxicity of the extract of hydroethanol Schinopsis brasiliensis Engl., Anacardiaceae, stem bark and its chloroform, hexane, ethyl acetate, and hydromethanol fractions against Artemia salina and Aedes Aegypti larvae and snails Biomphalaria glabrata. All of the assays were performed in triplicate and the mean mortality rates were used to determine the LC50 and LC90 values using the probit method. The hydroethanol hydromethanol extract and fraction were free of toxicity towards A. salina (LC50 > 1000 mu g/ml), while chloroform fraction was moderately toxic (LC50 313 mu g/ml); ethyl acetate and hexane fractions displayed low toxicity, with LC50 557 and 582 mu g/ml, respectively. Chloroform, hexane, and ethyl acetate fractions showed larvicidal potential towards A. aegypti (LC50 values of 345, 527 and 583 mu g/ml, respectively), while chloroform and ethyl acetate fractions were highly toxic to B. glabrata (LC90 values of 68 and 73 mu g/ml, respectively). Based on these findings, ethyl acetate, chloroform, and hexane fractions should be further investigated for their potential use against the vectors of dengue and schistosomiasis. (C) 2014 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
Palavras-Chave: Artemia salina; Aedes; Biomphalaria; Larvicide; Molluscicide; Schinopsis brasiliensis
Imprenta: Revista Brasileira de Farmacognosia, v. 24, n. 3, p. 298-303, 2014
Identificador do objeto digital: 10.1016/j.bjp.2014.07.006
Descritores: Aedes aegypti - Larvicide ; Aedes aegypti - Public health
Data de publicação: 2014
