Effects of Plasmodium gallinaceum on hemolymph physiology of Aedes aegypti during parasite development
Autor(es): Araujo, Ricardo Vieira; Maciel, Ceres; Hartfelder, Klaus; Capurro, Margareth Lara
Resumo: Insect disease vectors show diminished fecundity when infected with Plasmodium. This phenomenon has already been demonstrated in laboratory models such as Aedes aegypti, Anopheles gambiae and Anopheles stephensi. This study demonstrates several changes in physiological processes of A. aegypti occurring upon infection with Plasmodium gallinaceum, such as reduced ecdysteroid levels in hemolymph as well as altered expression patterns for genes involved in vitellogenesis, lipid transport and immune response. Furthermore, we could show that P. gallinaceum infected A. aegypti presented a reduction in reproductive fitness, accompanied by an activated innate immune response and increase in lipophorin expression, with the latter possibly representing a nutritional resource for Plasmodium sporozoites. (C) 2010 Elsevier Ltd. All rights reserved.
Palavras-Chave: Vitellogenesis; Hemolymph; Innate immune response; Aedes aegypti; Plasmodium gallinaceum
Imprenta: Journal of Insect Physiology, v. 57, n. 2, p. 265-273, 2011
Identificador do objeto digital: 10.1016/j.jinsphys.2010.11.016
Descritores: Aedes aegypti - Immunology
Data de publicação: 2011
