Autor(es): Yuan, J. Z.; Li, Q. F.; Huang, J. B.; Gao, J. F.

Resumo: Chlorfenapyr is a promising pyrrole insecticide with a unique mechanism of action that does not confer cross-resistance to neurotoxic insecticides. The effect of chlorfenapyr on pyrethorid-resistant Culex pipiens pallens Coq (Diptera: Culicidae) has not been fully investigated under laboratory conditions. In this study, cypermethrin-resistant C. p. pallens exhibited 376.79-fold and 395.40-fold increase in resistance to cypermethrin compared with susceptible strains after exposure for 24 and 48 h, respectively. Larvae and adults were tested for susceptibility using dipping, topical, and impregnated paper methods as recommended by the WHO. No cross-resistance to chlorfenapyr was found. Increased mortality was apparent between 48 and 72 h, indicating a slow rate of toxic activity. Synergism experiments with piperonyl butoxide (PBO) showed an antagonistic effect on chlorfenapyr toxicity. Mixtures of chlorfenapyr and cypermethrin could therefore provide additional benefits over either insecticide used alone. Mixtures of 5 ng/ml chlorfenapyr and 500 ng/ml cypermethrin exhibited a slight synergistic effect on cypermethrin-resistant mosquitoes (3.33, 6.84 and 2.34% after 24,48 and 72 h exposure, respectively. This activity was lost when the chlorfenapyr concentration was increased to 10 or 20 ng/ml. Chlorfenapyr showed quite good results for pyrethroid-resistant C. p. pallens, and could improve public health by reducing the occurrence of mosquito bites and subsequently protecting against transmission of lymphatic filariasis and Japanese encephalitis. (C) 2014 Elsevier B.V. All rights reserved.

Palavras-Chave: Culex pipiens pallens ; Chlorfenapyr ; Cypermethrin ; Resistance ; Piperonyl butoxide ; Cross - Resistance

Imprenta: Acta Tropica, v. 143, p. 13-17, 2015

Identificador do objeto digital: 10.1016/j.actatropica.2014.12.002

Descritores: Aedes aegypti - Public health

Data de publicação: 2015

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