Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.
Autor(es): Foo Suan-Sin,Chen Weiqiang,Taylor Adam,Sheng Kuo-Ching,Yu Xing,Teng Terk-Shin,Reading Patrick C,Blanchard Helen,Garlanda Cecilia,Mantovani Alberto,Ng Lisa F P,Herrero Lara J,Mahalingam Suresh
Resumo: The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic. The immune responses underlying alphavirus virulence remain enigmatic. We found that pentraxin 3 (PTX3) was highly expressed in CHIKV and RRV patients during acute disease. Overt expression of PTX3 in CHIKV patients was associated with increased viral load and disease severity. PTX3-deficient (PTX3(-/-)) mice acutely infected with RRV exhibited delayed disease progression and rapid recovery through diminished inflammatory responses and viral replication. Furthermore, binding of the N-terminal domain of PTX3 to RRV facilitated viral entry and replication. Thus, our study demonstrates the pivotal role of PTX3 in shaping alphavirus-triggered immunity and disease and provides new insights into alphavirus pathogenesis.
Imprenta: PLoS Pathogens, v. 11, n. 2, p. e1004649, 2015
Descritores: Zika virus - Real Time PCR
Data de publicação: 2015
