Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates
Autor(es): Dudley, Dawn M.; Rompay, Koen K. Van; Coffey, Lark L.; Ardeshir, Amir; Keesler, Rebekah I.; Bliss-Moreau, Eliza; Grigsby, Peta L.; Steinbach, Rosemary J.; Hirsch, Alec J.; MacAllister, Rhonda P.; Pecoraro, Heidi L.; Colgin, Lois M.; Hodge, Travis; Daniel N. , Tardif, Suzette; Patterson, Jean L.; Tamhankar, Manasi; Seferovic, Maxim; Aagaard, Kjersti M.; Sánchez-San Martín, Claudia; Chiu, Charles Y.; Panganiban, Antonito T.; Veazey, Ronald S.; Wang, Xiaolei; Maness, Nicholas J.; Gilbert, Margaret H.; Bohm, Rudolf P.; Waldorf, Kristina M. Adams; Gale Jr, Michael; Rajagopal, Lakshmi; Hotchkiss, Charlotte E.; Mohr, Emma L.; Capuano, Saverio V.; Simmons, Heather A.; Mejia, Andres; Friedrich, Thomas C.; Golos, Thaddeus G.; O'Connor, David H.
Resumo: Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection
Imprenta: Nature Medicine, v. 24, p. 1104-1107, 2018
Descritores: Zika virus - Infectious diseases; Zika virus - Viral infections
Data de publicação: 2018
