Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.

Autor(es): Bartholomay Lyric C; Waterhouse Robert M; Mayhew George F; Campbell Corey L; Michel Kristin; Zou Zhen; Ramirez Jose L; Das Suchismita; Alvarez Kanwal; Arensburger Peter; Bryant Bart; Chapman Sinead B; Dong Yuemei; Erickson Sara M; Karunaratne S H P Parakrama; Kokoza Vladimir; Kodira Chinnappa D; Pignatelli Patricia; Shin Sang Woon; Vanlandingham Dana L; Atkinson Peter W; Birren Bruce; Christophides George K; Clem Rollie J; Hemingway Janet; Higgs Stephen; Megy Karine; Ranson Hilary; Zdobnov Evgeny M; Raikhel Alexander S; Christensen Bruce M; Dimopoulos George; Muskavitch Marc A T

Resumo: The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

Imprenta: Science, v. 330, n. 6000, p. 88-90, 2010

Identificador do objeto digital: 10.1126/science.1193162.

Descritores: Aedes aegypti - Arbovirus ; Aedes aegypti - Flaviviridae ; Aedes aegypti - Genome ; Aedes aegypti - Pathogenesis ; Aedes aegypti - RNA ; Aedes aegypti - virus ; Aedes aegypti - Immunology ; Aedes aegypti - Public health

Data de publicação: 2010