Major essential oils composition and immunotoxicity activity from leaves of Foeniculum vulgare against Aedes aegypti L.

Autor(es): Chung Ill-Min; Ro Hee-Myong; Moon Huyng-In

Resumo: The leaves of Foeniculum vulgare (Umbelliferae) were extracted and the major essential oil composition and immunotoxicity effects were studied. The analyses conducted by gas chromatography and mass spectroscopy (GC-MS) revealed the essential oils of F. vulgare leaves. The F. vulgare essential oil yield was 0.97%, and GC/MS analysis revealed that its major constituents were methyl clavicol (46.3%), Î?-phellandrene (18.2%), fenchone (10.6%), (E)-anethole (11.3%), myrcene (3.4%), and Î?-pinene (2.1%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 41.23â??ppm and an LC(90) value of 65.24â??ppm. Also, methyl clavicol (â??98.0%), Î?-phellandrene (â??95.0%), fenchone (â??98.0%), (E)-anethole (â??99.0%), myrcene (â??99.0%), and Î?-pinene (â??99.0%) were tested against the F(21) laboratory strain of A. aegypti. Fenchone (â??98.0%) and (E)-anethole (â??99.0%) have medium activity with an LC(50) value of 73.11â??ppm and 102.41â??ppm. The above data indicate that major compounds interaction may play a more important role in the toxicity of essential oil.

Palavras-Chave: Aedes aegypti; Foeniculum vulgare; Essential oils; Immunotoxicity effects; Fenchone; (E)-anethole; Umbelliferae

Imprenta: Immunopharmacology and Immunotoxicology, v. 33, n. 3, p. 450-453, 2011

Identificador do objeto digital: 10.3109/08923973.2010.532805.

Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - Antibodies ; Aedes aegypti - Immunology ; Aedes aegypti - Public health

Data de publicação: 2011