Larvicidal effects of fungal Meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and Yellow fever.

Autor(es): Geris Regina; Rodrigues-Fo Edson; Garcia da Silva Heloísa Helena; Garcia da Silva Ionizete

Resumo: The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1-7, previously obtained fungal secondary metabolites from Penicillium sp., against the third-instar larvae of A. aegypti. The lethal concentrations (LC(50) and LC(90)) of 1-7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC(50) value of 2.9 ppm, making it an attractive natural insecticide.

Palavras-Chave: Larvicidal activity; Aedes aegypti; Mosquito; Dengue; Yellow fever; Meroterpenoids; Insecticides; Dehydroaustin; Metabolites

Imprenta: Chemistry & Biodiversity, v. 5, n. 2, p. 341-345, 2008

Identificador do objeto digital: 10.1002/cbdv.200890032

Descritores: Aedes aegypti - Molecular Structure ; Aedes aegypti - Viral infections ; Aedes aegypti - Molecular methods ; Aedes aegypti - Dengue ; Aedes aegypti - Public health

Data de publicação: 2008