Improved microwave-mediated synthesis of 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids and their larvicidal and fungal growth inhibitory properties.
Autor(es): Neves Filho Ricardo Antonio Wanderley; da Silva Cecília Aguiar; da Silva Clécia Sipriano Borges; Brustein Vanessa Passos; do Amaral Ferraz Navarro Daniela Maria; dos Santos Fábio André Brayner; Alves Luiz Carlos; dos Santos Cavalcanti Marília Gabriela; Srivastava Rajendra Mohan; das Graças Carneiro-Da-Cunha Maria
Resumo: The synthesis of 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids from arylamidoximes and succinic anhydride under focused microwave irradiation conditions is described. The new synthetic method furnished the desired products in 2-3 min and good yields. Furthermore, the previously complicated purification procedure has been simplified in a manner which is quick, eco-friendly and cost-effective. Larvicidal bioassay and fungal growth inhibitory tests were performed using several 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids. These acids presented strong larvicidal activity against L4 larvae of Aedes aegypti. The results suggest that larvicidal activity might be correlated with the presence of electron-withdrawing substituents in the para position of the phenyl ring except the fluorine atom. The alterations observed in the larvae spiracular valves of the siphon and anal papillae by 1,2,4-oxadiazoles in the larvicidal bioassay are responsible for larvae's death. Furthermore, all acids inhibited the fungal growth of five different types of fungi, viz., Fusarium solani, F. oxysporum, F. moniliforme, F. decemcellulare and F. lateritium in a preliminary evaluation. Both of these activities are being disclosed for the first time for 1,2,4-oxadiazole-5-yl ring linked at C-3 of propionic acid.
Imprenta: Chemical & Pharmaceutical Bulletin, v. 57, n. 8, p. 819-825, 2009
Identificador do objeto digital: https://doi.org/10.1248/cpb.57.819
Descritores: Aedes aegypti - Molecular Structure
Data de publicação: 2009