Immunotoxicity activity of sesquiterpenoids from black galingale (Kaempferia parviflora Wall. Ex. Baker) against Aedes aegypti L.
Autor(es): Moon Hyung-In; Cho Sang-Buem; Lee Jun-Hyeong; Paik Hyun-Dong; Kim Soo-Ki
Resumo: The roots of black galingale (Kaempferia parviflora) were chloroform-extracted and the isolated two sesquiterpene and immunotoxicity effects were studied. The structures and stereochemistry of these compounds were established on the basis of analysis of spectra including UV, MS, (1)H-NMR, and (13)C-NMR as follows: 1 (4Î?-acetoxycadina-2,9-diene-1,8-dione), 2 (1Î?,3Î?,4β-trihydroxy-9-cadinen-8-one). Compound 2 had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L. with an LC(50) value of 0.7 Î?M and an LC(90) value of 3.8 Î?M. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
Imprenta: Immunopharmacology and Immunotoxicology, v. 33, n. 2, p. 380-383, 2011
Identificador do objeto digital: 10.3109/08923973.2010.520717.
Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - Antibodies ; Aedes aegypti - Immunology
Data de publicação: 2011
