Genome sequence of Aedes aegypti, a major arbovirus vector.

Autor(es): Nene Vishvanath; Wortman Jennifer R; Lawson Daniel; Haas Brian; Kodira Chinnappa; Tu Zhijian Jake; Loftus Brendan; Xi Zhiyong; Megy Karyn; Grabherr Manfred; Ren Quinghu; Zdobnov Evgeny M; Lobo Neil F; Campbell Kathryn S; Brown Susan E; Bonaldo Maria F; Zhu Jingsong; Sinkins Steven P; Hogenkamp David G; Amedeo Paolo; Arensburger Peter; Atkinson Peter W; Bidwell Shelby; Biedler Jim; Birney Ewan; Bruggner Robert V; Costas Javier; Coy Monique R; Crabtree Jonathan; Crawford Matt; Debruyn Becky; Decaprio David; Eiglmeier Karin; Eisenstadt Eric; El-Dorry Hamza; Gelbart William M; Gomes Suely L; Hammond Martin; Hannick Linda I; Hogan James R; Holmes Michael H; Jaffe David; Johnston J Spencer; Kennedy Ryan C; Koo Hean; Kravitz Saul; Kriventseva Evgenia V; Kulp David; Labutti Kurt; Lee Eduardo; Li Song; Lovin Diane D; Mao Chunhong; Mauceli Evan; Menck Carlos F M; Miller Jason R; Montgomery Philip; Mori Akio; Nascimento Ana L; Naveira Horacio F; Nusbaum Chad; O'leary Sinéad; Orvis Joshua; Pertea Mihaela; Quesneville Hadi; Reidenbach Kyanne R; Rogers Yu-Hui; Roth Charles W; Schneider Jennifer R; Schatz Michael; Shumway Martin; Stanke Mario; Stinson Eric O; Tubio Jose M C; Vanzee Janice P; Verjovski-Almeida Sergio; Werner Doreen; White Owen; Wyder Stefan; Zeng Qiandong; Zhao Qi; Zhao Yongmei; Hill Catherine A; Raikhel Alexander S; Soares Marcelo B; Knudson Dennis L; Lee Norman H; Galagan James; Salzberg Steven L; Paulsen Ian T; Dimopoulos George; Collins Frank H; Birren Bruce; Fraser-Liggett Claire M; Severson David W

Resumo: We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.

Imprenta: Science, v. 316, n. 5832, p. 1718-1723, 2007

Identificador do objeto digital: 10.1126/science.1138878

Descritores: Aedes aegypti - Arbovirus ; Aedes aegypti - DNA ; Aedes aegypti - Genome ; Aedes aegypti - Molecular Structure ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - Viral infections ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Public health

Data de publicação: 2007