Genetic shifting: a novel approach for controlling vector-borne diseases.
Autor(es): Powell Jeffrey R; Tabachnick Walter J
Resumo: Rendering populations of vectors of diseases incapable of transmitting pathogens through genetic methods has long been a goal of vector geneticists. We outline a method to achieve this goal that does not involve the introduction of any new genetic variants to the target population. Rather we propose that shifting the frequencies of naturally occurring alleles that confer refractoriness to transmission can reduce transmission below a sustainable level. The program employs methods successfully used in plant and animal breeding. Because no artificially constructed genetically modified organisms (GMOs) are introduced into the environment, the method is minimally controversial. We use Aedes aegypti and dengue virus (DENV) for illustrative purposes but point out that the proposed program is generally applicable to vector-borne disease control.
Imprenta: Trends in Parasitology, v. 30, n. 6, p. 282-288, 2014
Identificador do objeto digital: 10.1016/j.pt.2014.04.005.
Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Infectious diseases ; Aedes aegypti - Viral infections ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Public health
Data de publicação: 2014