Autor(es): Black William C; Bennett Kristine E; Gorrochótegui-Escalante Norma; Barillas-Mury Carolina V; Fernández-Salas Ildefonso; de Lourdes Muñoz María; Farfán-Alé José A; Olson Ken E; Beaty Barry J

Resumo: Aedes aegypti is the primary vector of yellow fever (YF) and dengue fever (DF) flaviviruses worldwide. In this review we focus on past and present research on genetic components and environmental factors in Aedes aegypti that appear to control flavivirus transmission. We review genetic relationships among Ae. aegypti populations throughout the world and discuss how variation in vector competence is correlated with overall genetic differences among populations. We describe current research into how genetic and environmental factors jointly affect distribution of vector competence in natural populations. Based on this information, we propose a population genetic model for vector competence and discuss our recent progress in testing this model. We end with a discussion of approaches being taken to identify the genes that may control flavivirus susceptibility in Ae. aegypti.

Palavras-Chave: Aedes aegypti; Flavivirus; Vector competence; Population genetics

Imprenta: Archives of Medical Research, v. 33, n. 4, p. 379-388, 2002

Identificador do objeto digital: https://doi.org/10.1016/S0188-4409(02)00373-9

Descritores: Aedes aegypti - Cytopathology ; Aedes aegypti - Flaviviridae ; Aedes aegypti - Genome ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Viral infections ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Epidemiology ; Aedes aegypti - Public health

Data de publicação: 2002

INDICADORES

ACESSO