Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia.

Autor(es): D'Arena Giovanni; Vigliotti Maria Luigia; Pizza Vincenzo; Tartarone Alfredo; Volpe Giampiero; Iodice Giovanni; Di Renzo Nicola

Resumo: We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.

Imprenta: Leukemia & Lymphoma, v. 45, n. 7, p. 1489-1490, 2004

Identificador do objeto digital: 10.1080/10428190410001672149

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Inflammation

Data de publicação: 2004