Guillain-Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c.

Autor(es): Scharn N.; Ganzenmueller T.; Wenzel J. J.; Dengler R.; Heim A.; Wegner F.

Resumo: In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (PCR) from blood and stool. Phylogenetic analysis revealed a novel HEV genotype 3 isolate closely related to other subgenotype 3c isolates from pig livers purchased in Germany. This indicates an autochthonous, potentially food-related hepatitis E and is, to our knowledge, the first report about a neurological syndrome associated with an HEV subgenotype 3c infection.

Imprenta: Infection, v. 42, n. 1, p. 171-173, 2014

Identificador do objeto digital: 10.1007/s15010-013-0448-5

Descritores: Guillain-Barre Syndrome - DNA ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - RNA ; Guillain-Barre Syndrome - Serology ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Molecular screening

Data de publicação: 2014