Guillain-Barré syndrome as leading manifestation of graft-versus-host disease in an allogeneic bone marrow transplanted patient.

Autor(es): Thöne Jan; Lamprecht Susanne; Hohaus Andreas; Erbguth Frank; Bickel Andreas

Resumo: Guillain-Barré Syndrome (GBS) is the most frequent cause of neuromuscular paralysis in industrialized countries and usually occurs after respiratory and gastrointestinal infections. However, in rare cases GBS is associated with Graft-versus-Host Disease (GvHD). In the present case we report on a female allogeneic bone marrow transplanted patient who developed GBS as a leading manifestation of GvHD subsequent to discontinuation of her immunosuppressive medication with cyclosporine. In contrast to former case reports both IVIg and plasma exchange failed while resumption of immunosuppressive medication improved the condition of the patient clearly.

Imprenta: Journal of the Neurological Sciences, v. 292, p. 1-2, p. 114-116, 2010

Identificador do objeto digital: 10.1016/j.jns.2010.01.020

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies

Data de publicação: 2010