Guillain-Barré syndrome and glioblastoma.
Autor(es): Melguizo Isaac; Gilbert Mark; Tummala Sudhakar
Resumo: Guillain-Barré syndrome (GBS) is defined as an acute demyelinating peripheral neuropathy. We describe a case of GBS in a patient with glioblastoma undergoing chemotherapy treatment. A 57 year old woman diagnosed with glioblastoma developed a subacute progressive history of bilateral symmetric numbness of her fingers and toes, belt-type neuropathic pain, a left facial droop and upper and lower extremity muscle weakness. There was no evidence of a tumor mass or leptomeningeal disease in the spine. Electrophysiological studies confirmed the diagnosis. Although rare, GBS should be considered in primary brain tumor patients with generalized acute-subacute progressive weakness that is inconsistent with the location of their tumor, particularly if they are also on chemotherapy contributing to their immunosuppressive state.
Imprenta: Journal of Neuro-Oncology, v. 104, n. 1, p. 371-373, 2011
Identificador do objeto digital: 10.1007/s11060-010-0471-7
Descritores: Guillain-Barre Syndrome - Pathogenesis
Data de publicação: 2011
