Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.
Autor(es): Ma J. J.; Nishimura M.; Mine H.; Kuroki S.; Nukina M.; Ohta M.; Saji H.; Obayashi H.; Kawakami H.; Saida T.; Uchiyama T.
Resumo: We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain-Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positive (Cj+) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNF alpha secretion in the development of C. jejuni-related GBS.
Imprenta: Annals of Neurology, v. 44, n. 5, p. 815-818, 1998
Identificador do objeto digital: 10.1002/ana.410440517
Descritores: Guillain-Barre Syndrome - DNA ; Guillain-Barre Syndrome - Genome ; Guillain-Barre Syndrome - Molecular Structure ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1998
