Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome.
Autor(es): van Sorge Nina M.; Yuki Nobuhiro; Koga Michiaki; Susuki Keiichiro; Jansen Marc D.; van Kooten Cees; Wokke John H. J.; van de Winkel Jan G. J.; van der Pol W-Ludo.; van den Berg Leonard H.
Resumo: The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcalphaRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS.
Imprenta: Journal of Neuroimmunology, v. 182, n. 1-2, p. 177-184, 2007
Identificador do objeto digital: 10.1016/j.jneuroim.2006.10.015
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2007
