Gammadelta T cell non-responsiveness in Campylobacter jejuni-associated Guillain-Barré syndrome patients.

Autor(es): Van Rhijn I.; Logtenberg T.; Ang C. W.; Van den Berg L. H.

Resumo: To seek evidence for a role of molecular mimicry in the induction of Guillain-Barré syndrome (GBS), the authors studied Campylobacter jejuni-reactive T lymphocytes in patients with GBS. In contrast to controls, gammadelta T cells of patients with GBS with antecedent C jejuni infections failed to respond to C jejuni. supl.ementing cell cultures with the cytokines interleukin-2 or interleukin-15 resulted in restoration of the gammadelta T cell proliferative response. Gammadelta T cell non-responsiveness may lead to defective regulation of antibody production, and in this way an (auto)immune response against ganglioside-like epitopes on peripheral nerve may cause GBS.

Imprenta: Neurology, v. 61, n. 7, p. 994-996, 2003

Identificador do objeto digital: 10.1212/01.WNL.0000083986.53792.90

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2003