Feature selection for better identification of subtypes of Guillain-Barré syndrome.

Autor(es): Hernández-Torruco José; Canul-Reich Juana; Frausto-Solís Juan; Méndez-Castillo Juan José

Resumo: Guillain-Barré syndrome (GBS) is a neurological disorder which has not been explored using clustering algorithms. Clustering algorithms perform more efficiently when they work only with relevant features. In this work, we applied correlation-based feature selection (CFS), chi-squared, information gain, symmetrical uncertainty, and consistency filter methods to select the most relevant features from a 156-feature real dataset. This dataset contains clinical, serological, and nerve conduction tests data obtained from GBS patients. The most relevant feature subsets, determined with each filter method, were used to identify four subtypes of GBS present in the dataset. We used partitions around medoids (PAM) clustering algorithm to form four clusters, corresponding to the GBS subtypes. We applied the purity of each cluster as evaluation measure. After experimentation, symmetrical uncertainty and information gain determined a feature subset of seven variables. These variables conformed as a dataset were used as input to PAM and reached a purity of 0.7984. This result leads to a first characterization of this syndrome using computational techniques.

Imprenta: Computational and Mathematical Methods in Medicine, 2014

Identificador do objeto digital: 10.1155/2014/432109

Descritores: Guillain-Barre Syndrome - Serological diagnosis ; Guillain-Barre Syndrome - Public health

Data de publicação: 2014