Fc receptor like 3 in Chinese patients of Han nationality with Guillain-Barré syndrome.

Autor(es): Sang Daoqian; Chen Qiming; Liu Xiaolin; Qu Hongdang; Wei Daoxiang; Yin Liang; Zhang Lina

Resumo: Fc receptor like 3 gene (FcRL3) has been associated with some autoimmune diseases. Here, its role in Guillain-Barré syndrome (GBS) was evaluated by studying nine FcRL3 gene SNPs in a Chinese cohort of GBS patients. The frequencies of FcRL3-3-169C, FcRL3-6 intron3A, and FcRL3-8 exon15G alleles were significantly increased in GBS patients compared with healthy controls. The frequency of FcRL3-1?9 CCTGGAGAA haplotype was significantly increased, and the frequencies of FcRL3-1?9 CCTACAAAA,CCCACGAAA, and CCTGCGGAA haplotypes were significantly decreased compared with healthy controls. These results suggest that FcRL3 is associated with GBS incidence.

Imprenta: Journal of Neuroimmunology, v. 246, n. 1-2, p. 65-68, 2012

Identificador do objeto digital: 10.1016/j.jneuroim.2012.03.006

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2012