Expression of Toll-like receptors 2, 4 and 9 in patients with Guillain-Barré syndrome.
Autor(es): Wang Yu-Zhong; Liang Qiu-Hua; Ramkalawan Hhoonisha; Wang Yan-Li; Yang Yan-Fang; Zhou Wen-Bin; Tian Fa-Fa; Li Jing; Yang Huan
Resumo: A myriad of transcription factors and inflammatory cytokines have been described to participate in the pathogenesis of Guillain-Barré syndrome (GBS). However, the innate immunity components--Toll-like receptors (TLRs)--have never been explored in this disease. We therefore investigated the expression of TLR2, 4 and 9 in the peripheral circulation of GBS patients as well as healthy controls. Twenty-one GBS patients and 21 healthy donors participated in this study. Peripheral blood mononuclear cells were used for mRNA and protein analysis of TLR-related molecules. Also, peripheral blood mononuclear cells from different subjects were incubated with different TLR agonists and the subsequent IFN-? secretion was determined. Expression of TLR2, 4 and 9 as well as their related signaling molecules were higher in GBS patients compared to healthy controls. Disability scores of GBS patients had a strong positive correlation with the high levels of expression of TLR2, 4 and 9. The TLR signaling pathway may be involved in the pathogenesis of GBS.
Imprenta: Neuroimmunomodulation, v. 19, n. 1, p. 60-68, 2012
Identificador do objeto digital: 10.1159/000328200
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - RNA ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2012
