Autor(es): Garg Ravindra Kumar,Malhotra Hardeep Sing,Verma Rajesh,Sharma Pawan,Singh Maneesh Kumar

Resumo: Hypokalemic paralysis is characterized by episodes of acute muscle weakness associated with hypokalemia. In this study, we evaluated the possible etiological factors in patients of hypokalemic paralysis. We reviewed the records of 29 patients who were admitted with a diagnosis of hypokalemic paralysis. Modified Guillain-Barre´ Syndrome disability scale was used to grade the disability. In this study, 15 (51.7%) patients had secondary causes of hypokalemic paralysis and 14 patients (42.3%) had idiopathic hypokalemic paralysis. Thyrotoxicosis was present in six patients (20.6%), dengue infection in four patients (13.7%), distal renal tubular acidosis in three patients (10.3%), Gitelman syndrome in one patient (3.4%), and Conn's syndrome in one patient (3.4%). Preceding history of fever and rapid recovery was seen in dengue infection-induced hypokalemic paralysis. Approximately 62% patients had elevated serum creatinine phosphokinase. All patients had recovered completely following potassium supl.ementation. Patients with secondary causes were older in age, had significantly more disability, lower serum potassium levels, and took longer time to recover. In conclusion, more than half of patients had secondary causes responsible for hypokalemic paralysis. Dengue virus infection was the second leading cause of hypokalemic paralysis, after thyrotoxicosis. Presence of severe disability, severe hypokalemia, and a late disease onset suggested secondary hypokalemic paralysis.

Palavras-Chave: Acute flaccid paralysis, dengue virus, hypokalemia, hypokalemic paralysis

Imprenta: Annals of Indian Academy of Neurology, v. 16, n. 3, p. 365-370, 2013

Identificador do objeto digital: 10.4103/0972-2327.116934

Descritores: Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Dengue

Data de publicação: 2013

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