Ethyl mercury poisoning during a protein A immunoadsorption treatment.
Autor(es): Koch Michael; Trapp Rudolf
Resumo: We describe the case of a 38-year-old woman with Guillain-Barré syndrome who was accidentally intoxicated with thimerosal, a column disinfectant containing ethyl mercury, during a protein A immunoadsorption treatment. The 1-time overdose caused by an equipment handling error led to a maximum blood serum mercury level of 2,250 microg/L, thus exceeding the normal blood reference range by a factor of approximately 200. Although the patient did not show short-or long-term clinical signs of mercury intoxication, she was treated with chelation therapy, and we replaced thimerosal with a commercially available mercury-free disinfectant, suggesting that thimerosal is no longer indicated for preservation of protein A columns.
Imprenta: American Journal of Kidney Diseases, v. 47, n. 2, p. 31-34, 2006.
Identificador do objeto digital: 10.1053/j.ajkd.2005.10.026
Descritores: Guillain-Barre Syndrome - Proteins
Data de publicação: 2006
