Autor(es): Shin Taekyun; Ahn Meejung; Moon Changjong; Kim Seungjoon

Resumo: Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central nervous system. This review focuses on experimental evidence documenting the neuroprotective effects of EPO in organ-specific autoimmune nervous system disorders such as experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN). In addition, the immunomodulatory role of EPO in the pathogenesis of EAE and EAN animal models of human multiple sclerosis and Guillain-Barré syndrome, respectively, will be discussed.

Palavras-Chave: Autoimmune diseases, Encephalomyelitis, Erythropoietin, Experimental autoimmune neuritis, Neuroinflammation, Neuroprotection

Imprenta: Anatomy & Cell Biology, v. 45, n. 4, p. 215-220, 2012

Identificador do objeto digital: 10.5115/acb.2012.45.4.215

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis

Data de publicação: 2012

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