Elevated levels of cerebrospinal fluid and plasma interleukin-37 in patients with Guillain-Barré syndrome.
Autor(es): Li Cong; Zhao Pingwei; Sun Xiguang; Che Yuanyuan; Jiang Yanfang
Resumo: AIMS. Interleukin-37 (IL-37) is an anti-inflammatory cytokine. This study aims to investigate the concentrations of plasma and cerebrospinal fluid (CSF) IL-37 in patients with Guillain-Barré Syndrome (GBS). The levels of plasma and CSF IL-37, IL-17A, IFN- ? , and TNF- ? in 25 GBS patients and 20 healthy controls (HC) were determined by enzyme-linked immunoabsorbent assay and flow cytometric bead array assay, respectively. The values of clinical parameters in the patients were also measured. The concentrations of plasma IL-37, IL-17A, IFN- ? , and TNF- ? and CSF IL-37 and IL-17A in patients at the acute phase of GBS were significantly higher than those in the HC. The levels of plasma IL-37, IL-17A, IFN- ? , and TNF- ? were positively correlated in those patients, and the levels of CSF IL-37 and IL-17A as well as the levels of plasma TNF- ? were correlated positively with the GBS disability scale scores (GDSs) in those patients. Treatment with intravenous immunoglobulin significantly reduced the levels of plasma IL-37, IL-17A, IFN- ? , and TNF- ? in the drug-responding patients. Our findings indicate higher levels of plasma and CSF IL-37 and IL-17A and other proinflammatory cytokines in patients with GBS.
Imprenta: Mediators of Inflammation, 2013
Identificador do objeto digital: 10.1155/2013/639712
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Inflammation ; Guillain-Barre Syndrome - Public health
Data de publicação: 2013
